Susan Mandel earned her doctorate in psychology from the University of Cincinnati in 1968. She worked as a staff psychologist at Alameda County Hospital prior to becoming Director of Mental Health for the County in 1975. In 1980, she became CEO of Pasadena Child Guidance Clinics, which became Pacific Clinics in 1987, and oversaw its growth from a small non-profit with a budget under $1 million to a large, multi-cultural network of clinics with a budget of nearly $100 million. In 2007, Pacific Clinics merged with Portals. Mandel has been active on the State Mental Health Planning Council and on the California Council of Community Mental Health Agencies

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